BRAINIACS

Figure 1: Methodological approach of the BRAINIACS project: closely linking experiments, modeling, and simulation.

Brain tissue is not only one of the most important but also the most complex and compliant tissue in the human body. While long underestimated, increasing evidence confirms that mechanics plays a critical role in modulating brain function and dysfunction. The Emmy-Noether research group BRAINIACS – BRAIn mechaNIcs ACross Scales – aims to establish novel computational tools based on nonlinear continuum mechanics that can facilitate early diagnostics of neurological diseases and advance modern treatment strategies. We bridge the scales from known biological processes on the cellular scale to macroscopic pathologies apparent through modern imaging techniques.
To achieve this goal, our group combines experimental and microstructural analyses with continuum scale modeling and simulation. Performing experiments hand in hand with modeling and simulation allows us to continually optimize both experimental and numerical procedures. Through the simultaneous investigation of mechanics and microstructure, we aim to not only understand the regional variations in brain structure and function, but also to quantify the adaptation of cells to changes in their mechanical environment.
Solved within a finite element framework, those models will help us to foresee the behavior of brain tissue under physiological and pathological conditions, and to simulate progression of disease or mechanically-induced loss of brain function.

BRAINIACS lab video

From September 7-9, we participated in the 17th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, which was originally planned to take place in Bonn, Germany, but was now held online due to the current Covid-19 situation. BRAINIACS PhD students Nina Reiter...

After a long time of Zoom meetings only, we finally had the chance to meet in person again. We shot our first lab movie, produced by our talented Hiwi Biswaroop Roy, which turned out great and was a lot of fun. Later, we went to the Beergarden to celebrate the achievements of the year so far and e...

We are honored to be part of the television broadcast ‘Wir sind #FAU – Innovation leben’ (We are #FAU – Bringing innovation to life), which was dedicated to alumni celebrating the anniversary of completing their doctoral degree and focused on outstanding personalities and alumni from research, indus...

Beginning of June, the 5th Soft Tissue Modelling Workshop was held online by the University of St. Andrews, Scotland, focusing on state-of-the-art developments and challenges in the field of soft tissue modeling. BRAINIACS Master student Alex presented our recent work on "Poro-viscoelastic effects...

On May 4, 2021, four female and six male researchers received the Heinz Maier-Leibnitz Prize 2021, the top award for early career investigators in Germany. Congratulations to all awardees. We are deeply honored that the research by the BRAINIACS group was acknowledged through such an exceptional a...