BRAINIACS

Figure 1: Methodological approach of the BRAINIACS project: closely linking experiments, modeling, and simulation.

Brain tissue is not only one of the most important but also the most complex and compliant tissue in the human body. While long underestimated, increasing evidence confirms that mechanics plays a critical role in modulating brain function and dysfunction. The Emmy-Noether research group BRAINIACS – BRAIn mechaNIcs ACross Scales – aims to establish novel computational tools based on nonlinear continuum mechanics that can facilitate early diagnostics of neurological diseases and advance modern treatment strategies. We bridge the scales from known biological processes on the cellular scale to macroscopic pathologies apparent through modern imaging techniques.
To achieve this goal, our group combines experimental and microstructural analyses with continuum scale modeling and simulation. Performing experiments hand in hand with modeling and simulation allows us to continually optimize both experimental and numerical procedures. Through the simultaneous investigation of mechanics and microstructure, we aim to not only understand the regional variations in brain structure and function, but also to quantify the adaptation of cells to changes in their mechanical environment.
Solved within a finite element framework, those models will help us to foresee the behavior of brain tissue under physiological and pathological conditions, and to simulate progression of disease or mechanically-induced loss of brain function.

BRAINIACS lab video

From June 5 to June 9, the 8th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS Congress 2022) was held in Oslo, Norway. For many of us it was the first large fully in-person conference after the Covid-19 pandemic, with more than 2000 participants. We organiz...

To celebrate our new BRAINIACS Hoodies, we relocated our regular BRAINIACS meeting to the nice Röthelheim beergarden in Erlangen. The weather was perfect – sunny yet not too hot such that the hoodies were the perfect wardrobe. It is really special to experience the great atmosphere and spirit wi...

On May 11, BRAINIACS PhD students Alex and Jessi kindly hosted a BBQ on their roof terrace. It was a great and inspiring atmosphere, where we had the chance to talk about research but also everything else that matters in life. It was also a great opportunity to introduce our newest BRAINIACS membe...

On May 7, PI Silvia Budday gave an invited lecture in the Symposium “Evolution and cortical expansion of the human brain” at the ISDN 2022, the 24th Biennial Meeting of the International Society for Developmental Neuroscience. The other Symposium speakers were Fumio Matsuzaki, RIKEN Center for Biosy...

PI Silvia Budday gave an invited talk at the Euromech Colloquium 627 on “Current Challenges in Soft Tissue Mechanics” organized by Stéphane Avril (MINES St. Etienne, France), Nele Famaey (KU Leuven, Belgium), and Christopher Blase (Frankfurt University of Applied Sciences, Germany) April 6 – 8 202...