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BRAINIACS

Figure 1: Methodological approach of the BRAINIACS project: closely linking experiments, modeling, and simulation.

Brain tissue is not only one of the most important but also the most complex and compliant tissue in the human body. While long underestimated, increasing evidence confirms that mechanics plays a critical role in modulating brain function and dysfunction. The Emmy-Noether research group BRAINIACS – BRAIn mechaNIcs ACross Scales – aims to establish novel computational tools based on nonlinear continuum mechanics that can facilitate early diagnostics of neurological diseases and advance modern treatment strategies. We bridge the scales from known biological processes on the cellular scale to macroscopic pathologies apparent through modern imaging techniques.
To achieve this goal, our group combines experimental and microstructural analyses with continuum scale modeling and simulation. Performing experiments hand in hand with modeling and simulation allows us to continually optimize both experimental and numerical procedures. Through the simultaneous investigation of mechanics and microstructure, we aim to not only understand the regional variations in brain structure and function, but also to quantify the adaptation of cells to changes in their mechanical environment.
Solved within a finite element framework, those models will help us to foresee the behavior of brain tissue under physiological and pathological conditions, and to simulate progression of disease or mechanically-induced loss of brain function.

Although the famous Bergkirchweih in Erlangen had to be cancelled due to Covid-19, we had our private celebration over Zoom. The special Zoom-Background by the FAU immediately created the appropriate atmosphere and Alex definitely won the 'Costume Contest'. We had a great afternoon talking about a l...

Proud of the BRAINIACS team, who has even increased productivity during these difficult times. We try to stay home but still keep everything going. Many thanks to all members of the team fo their enthusiastic engagement. Stay healthy!

On 12th of March we had our BRAINIACS meeting under special circumstances. Despite disinfecting agent and social distancing, everyone actively presented the progress of their individual projects. We had inspiring discussions on future steps. It is great to see how all BRAINIACS members support each ...

On 14th of February, Silvia Budday was a referee at the PhD defence of Dr. Annaclaudia Montanino from the Division of Neuronic Engineering at KTH in Stockholm, Sweden. Congratulations to Annaclaudia for a persuasive performance and a great thesis with the title "Definition of Axonal Injury Toleran...

On December 13, we had our 2nd BRAINIACS meeting and Christmas party. It was a great platform to practice student seminar presentations, and to exchange our newest findings, challenges, and perspectives in a warm Christmassy atmosphere. Thanks to everyone for being such a great team and for your g...